Research

Genetic variation influences pluripotency

How genetic variation shapes ground-state pluripotency in mouse embryonic stem cells using chromatin accessibility, transcript, and protein abundance data across genetically…

Dissecting the Effects of Genetic Variation on Stress Response

quantitative genetics

yeast

signaling dynamics

QTL mapping

Using osmo-adaptation in budding yeast as a model to understand how genetic variation across diverse strains drives differences in signaling dynamics and phenotypic…

Single-Cell Analysis Reveals Mechanisms of Gene Regulation

Measuring nutrient stress response in single yeast cells using phase and luminescence microscopy and microfluidics to uncover dose-dependent mechanisms of gene regulation.

Mathematical Modeling of Cellular Signaling

mathematical modeling

systems biology

NFκB signaling

hepatocytes

Modeling TNFα-induced NFκB signaling in primary murine hepatocytes using quantitative experimental data and parameter estimation to understand dynamic signal transduction.